Last step Answer bank Malate dehydrogenase in the cytoplasm oxidizes malate come oxaloacetate. Phosphoenolpyruvate carboxykinase decarboxylates and also phosphorylates oxaloacetate, developing phosphoenolpyruvate. 12 In the mitochondrion, pyruvate carboxylase switch pyruvate to oxal Malate dehydrogenase in the mitochondrion to reduce oxaloacetate to 09 In the cytoplasm, pyruvate carboxylase converts pyruvate to oxaloace Pyruvate decarboxylase switch oxaloacetate to phosphoenolpyruvate.


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Sol Griven data, The critical Converts enolpyuvate ascolysts action of come Pysuwate Pyouvate kinase Phosphoenalpysuwate+ADP Pyouvate ATP 3/mol 5 Ka/ma AG eaction is +31 K3/mo) The A.G that the evesse C+nu5 FCamo native of e Giluconeo genests the n-Casbohy drate compound Substrates or guconeogenests ase lactate PTuvate, min adas, propian ate Qnd yceo Synthests The Gluceonengeness the Precusos just fo Cytosd, b OCcusS mitochondsia developed of Pvateto in Conver sion In the Mitochondsia and Phosphoenol pyawate Cytosol Step- 1 Psrwate arboxylase a biotin, Tt counter Pyuvate come Oxaloacetate and also Co existence of ATP
Oxaloace-taie Tmpeameable, Canet be sent of mtochondsfa So, that is Conver-ted to malate. Step-a inmito chondsi dehy deggenase Malate Synthest3ed in Convests Oxaloacetate malate mito chon dsfal ma-loix-to toCytosol tranparted Malate Stop-3 Malate dehydvogenase esponsrble for Deaction in Cytosol a deversible Oxaloacetate malate to Convests Step-4 Carbory- kinase in Cytosol Phospho enolpysuvate come phospho enolpy ote (Pe) converts Oxalo acetate hnagh Enegi phosphate oxaloacetate to fsom PEp The Enayme -toansfis band fom GITP to Cos Ond 1besated


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Therefose Frrst step Th he mto chondsion, Pyuvate Casboxylase Corwerts Puvate come Oxaloacetate Malate dehydso genase n -the mtochon dofoo Deduces Oxaloace tate -to malate Malate dehy dogen Cytoplasm in the ase Oid?3es malate to OKaloacetate. Phosphoenolpyuvate Carboxgkinase de carbokylates Oxalo acetate, fomi and also Phosphoylates Phosphoenolpyrwate Last step