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You are watching: Which structure can secrete a substance into the environment surrounding the body?

StatPearls . Treasure Island (FL): StatPearls Publishing; 2021 Jan-.


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Introduction

A gland is a practical unit of cells the works with each other to create and also release a product into a duct or straight to the bloodstream. Two principal types of glands exist: exocrine and endocrine. The an essential difference in between the two species is that, whereas exocrine glands secrete substances right into a ductal mechanism to an epithelial surface, endocrine glands secrete products directly right into the bloodstream <1>. Exocrine secretions type in the acinus, a little cluster of cell at the origination the glandular ducts. Exocrine glands subclassify right into subtypes based on the method of secretion, the compound produced, or the shape of the gland.


Issues that Concern

This write-up will discuss:


Various cell species found in ~ the exocrine gland, and also their functions
Embryologic development of exocrine glands
Organ systems impacted by exocrine physiology
Functions that exocrine glands
Related clinical testing
Pathophysiology the exocrine glands
Significant clinical aspects

Cellular

Exocrine glands are consisted of of an acinus and a duct with different cell types, respectively. These glands are uncovered in many organs in ~ the body and also demonstrate a huge variety in the role of your secretions.  together such, a wide selection of cell varieties exists in exocrine glands.

While the duct functions primarily to transfer glandular secretions, the acinus is responsible for the manufacturing of glandular secretions, and also as such, shows much more variety in moving composition. Common cell varieties within the acinus include serous, mucinous, or sebaceous.


Mucinous glands secrete mucus, a typical example gift Brunner glands in the duodenum.
Sebaceous glands secrete sebum, one oily compound. Sebaceous glands are many prevalent in the face, scalp, groin, and also armpits. Cell types can be identified histologically together well.  Mucous cells typically stain lighter 보다 their serous counterparts when stained with hematoxylin and also eosin.

As ducts move from the acinus towards the last target, secretions initially go into the intralobular duct. Intralobular ducts have a simple cuboidal epithelium generally surrounded by parenchyma. Intralobular ducts drainpipe into interlobular ducts, which room a an easy columnar epithelium. The final ductal unit is the interlobar duct recognized by a stratified columnar epithelium. Connective tissue surrounds both interlobular and interlobar ducts.


Development

The early manifestation that exocrine gland formation is epithelial budding result from a complex interaction in between mesenchymal and also epithelial cabinet populations <3>. This initial duration of ingrowth is influenced by fibroblast development factors, many notably FGF10 and cadherin-2 <4>. Other transcription components that have actually been displayed to contribute to epithelial budding incorporate HlxB9, Isl1, LEF-1, Msx1/2, Pbx1, Pdx1, and also Tbx3 <5>.

Following the initial development of the epithelial bud, ductal elongation occurs. This procedure undergoes mediation by a big group of molecular signal such as Netrin-1, TIMP1, amphiregulin, IGF1, and also leukemia inhibitory factor <5>. Several matrix metalloproteinases (MMPs) contribute assistance through basement membrane renewal and also facilitate ductal elongation <6><7>. ~ an initial duration of ductal elongation, the exocrine gland begins to form ductal branches. NF-kappa-B is thought to beat a role <8>, and also sonic hedgehog and Wnts <3>. Together the duct begins to elongate, the acinus undergoes a duration of cell proliferation and differentiation. Due to the large variety in exocrine gland function, the exact number of cellular signals and interactions is immense. In general, however, a huge role exists for cell adhesion molecules such together laminin and also cadherins <9>.

Exocrine morphogenesis is a quick process. Ductal elongation and also branching generally occur in much less than a week, with acini formation arising 5 come 9 work later <10><11>. In a relatively short developmental period, exocrine glands type and can begin secreting a functional product.


Organ equipment Involved

Due to the varied number and duty of epithelial surface in the body, countless organ systems utilize exocrine glands to bring out their respective actions. Several examples will be included here, consisting of skin, mouth, stomach, pancreas, duodenum, and also breasts. 

Skin

The skin has a selection of exocrine glands, including the eccrine sweat glands and also sebaceous glands. Eccrine sweat glands space the many widespread sweat gland in the body and also are present on virtually every external body surface. The sweat produced is clean with tiny to no oil, in contrast to sebaceous glands, likewise found ~ above the skin, which secretes the an ext oily problem sebum.  

Salivary Glands

The salient glands in the mouth are one more example of exocrine glands and include the parotid glands, submandibular glands, and sublingual glands. While every gland has a unique mixture that serous and mucous cells, together, the outstanding glands plot to begin the procedure of food cradle while also lubricating and also protecting the mucosal surfaces.

Stomach

The stomach holds multiple species of exocrine glands that include pyloric glands, cardiac glands, and fundic glands. These glands incorporate numerous different cabinet types, including parietal cells, chief cells, and G cells. Together they regulate the gastric pH, relax enzymes to malfunction food commodities to a digestible form, and also assist with the absorb of necessary vitamins and minerals.  

Pancreas

The pancreas has both an endocrine and an exocrine function. The exocrine kidnize assists in food cradle by releasing a secretion wealthy in bicarbonate, which helps to neutralize the acidic environment produced in the stomach. The secretion also includes cradle enzymes.

Duodenum

Brunner glands are current in the duodenum of the little intestine. These exocrine glands space submucosal and produce a mucous product the protects the duodenum from mountain released native the stomach. The alkaline nature that the secretion additionally activates intestinal enzymes to assist with food failure and absorption.

Breast

The mammary gland is just one of the many well-known examples of an exocrine gland uncovered in the breast. Mammary glands develop milk well-off in nutrients that likewise provides passive immune to a baby’s immune system.


Function

The specific duty of exocrine glands in ~ the body varies through location and also organ system. However, the primary function is to create a secretion which ultimately gets released v a ductal system onto one epithelial surface. Examples encompass secretions that assist in food digestion, mucosal protection, thermoregulation, lubrication, and also nutrition.


Mechanism

The three mechanisms whereby exocrine glands release their secretions encompass merocrine, apocrine, and also holocrine.


Merocrine glands room the most typical subtype. By definition, merocrine gland secretions leave the cell via exocytosis. In this technique of secretion, there is no cabinet damage. An instance of merocrine cheap is the eccrine sweat gland. 
Apocrine glands, in contrast, form buds the the membrane which rest off into the duct, losing component of the cellular membrane in the process. A famous apocrine gland is the breastmilk-producing mammary gland. 
The last subtype that excretion is holocrine, in i m sorry the moving membrane ruptures to release its product into the duct. Sebaceous glands are a depiction of holocrine secretion.

Related Testing

In general, trial and error for an separation, personal, instance exocrine gland function is no performed. However, dysfunction the exocrine glands can produce a wide selection of clinical manifestations.

Imaging might be carry out to confirm a diagnosis of blocked glands. Sialolithiasis refers to instances where a rock becomes lodged within the outstanding gland or duct, and sialoadenitis refers to inflammation of the gland. CT and ultrasound are reliable methods that identifying and localizing stones <12>.

The liver chin acts as an exocrine gland once creating and excreting bile to it is in stored in the gallbladder, awaiting expulsion and release v the pancreatic duct into the duodenum. Obstruction, in ~ any allude in this pathway, can cause cholecystitis because of inflammation and also dysfunction that the gallbladder. Ultrasound is the early diagnostic check to diagnose cholecystitis <13>.

In cystic fibrosis, sodium and chloride room not reabsorbed in ~ the sweat duct because of a dysfunctional CFTR protein, causing abnormally salty skin. The sweat chloride test is the major test because that the diagnosis of cystic fibrosis <14>.

Pancreatic insufficiency occurs as soon as the exocrine glands that the pancreas are no much longer able to develop the cradle enzymes crucial for food malfunction in the small intestine. Typical etiologies include chronic pancreatitis, cystic fibrosis, and also hereditary hemochromatosis. Numerous methods deserve to be supplied to advice the role of the exocrine pancreas. Fat malabsorption have the right to lead to deficiencies in fat-soluble vitamin A, D, E, and K. Thus, vitamin levels have the right to be provided to calculation pancreatic function <15>. Fecal elastase-1 testing is another technique with fairly high specificity and also sensitivity. Short levels that fecal elastase-1 show a poorly work exocrine pancreas <16>. The most sensitive diagnostic an approach for exocrine pancreatic insufficiency, however, is utilizing direct pancreatic role tests such together the cholecystokinin (CCK) or secretin stimulation test <17>.


Pathophysiology

Sjogren Syndrome

Sjogren’s syndrome is commonly connected with rheumatoid arthritis and also other rheumatic diseases. The syndrome is one autoimmune disorder that demonstrates decreased lacrimal and salivary gland duty that can additionally have connected systemic symptoms <18><19>. The condition is characterized by eye and also mouth dryness due to the gland dysfunction.  because of mouth dryness, patients v Sjogren syndrome present increased rates of dental candidiasis and also dental caries <18><20>. 

Cystic Fibrosis

Cystic fibrosis is an autosomal recessive disease that causes impaired chloride transport due to a mutation that the CFTR protein.  since CFTR is connected in the manufacturing of sweat, mucus, and digestive fluids, the mutation reasons a straight effect on exocrine gland secretions.  Indeed, about 90% of infants born with cystic fibrosis will develop pancreatic insufficiency by one year of age <21>.

Acne vulgaris

The pervasiveness of acne is an approximated 35 to 90% in adolescents <22>. The disorder influence the pilosebaceous unit, of i m sorry sebaceous glands space an example. The pathogenesis is multifactorial and also often entails hyperkeratinization the the follicle, increased sebum production, and also proliferation of Propionibacterium acnes with linked inflammation. Together sebum accumulates, an open up comedo forms, likewise known as a white head. Hyperkeratinization and also increased sebum production lead to clogging that the pores the the pilosebaceous unit. As the lipids in ~ sebum oxidize, the follicular orifice opens, creating an open comedo, or blackhead.

Treatment because that acne largely depends top top the severity of inflammation symptoms, but topical retinoids space usually the first-line treatment, return antimicrobial agents are an additional option for refractory cases <23>. For severe cases of nodulocystic acne or for patients who have failed treatment with systemic antibiotics, oral isotretinoin the therapeutic choice <24>.

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Clinical Significance

The exocrine gland have the right to be found in many organs and also serves a wide selection of functions within the body. As result of this fact, an understanding of the physiology that exocrine glands is essential for healthcare workers. Exocrine glands play a crucial role in the physiology of countless organ systems from the skin come the pancreas, providing the body through a an approach to relax secretions containing proteins, mucus, and also other commodities to epithelial surfaces around the body. Owing to your varied and essential roles, the dysfunction the exocrine glands is connected with illness as wide-ranging as acne vulgaris to Sjogren syndrome.


Murphrey MB, Safadi AO, Vaidya T. StatPearls . StatPearls Publishing; sweetheart Island (FL): Aug 11, 2021. Histology, Apocrine Gland.
Holmberg KV, Hoffman MP. Anatomy, biogenesis and regeneration of salient glands. Monogr dental Sci. 2014;24:1-13.
Govindarajan V, Ito M, Makarenkova HP, Lang RA, Overbeek PA. Endogenous and also ectopic gland induction by FGF-10. Dev Biol. 2000 Sep 01;225(1):188-200.
Wang J, Laurie GW. Organogenesis the the exocrine gland. Dev Biol. 2004 Sep 01;273(1):1-22.
Witty JP, wright JH, Matrisian LM. Matrix metalloproteinases space expressed during ductal and alveolar mammary morphogenesis, and misregulation the stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol Biol Cell. 1995 Oct;6(10):1287-303.
Sympson CJ, Talhouk RS, Alexander CM, Chin JR, Clift SM, Bissell MJ, Werb Z. Target expression the stromelysin-1 in mammary gland provides proof for a function of proteinases in branching morphogenesis and also the need for an intact basement membrane because that tissue-specific gene expression. J cabinet Biol. 1994 May;125(3):681-93.
Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, Medina D, Matrisian LM, Kerr LD, Yull FE. Atom factor-kappaB (NF-kappaB) regulates proliferation and also branching in mouse mammary epithelium. Mol Biol Cell. 2001 May;12(5):1445-55.
Yurchenco PD, Amenta PS, Patton BL. Basement membrane assembly, security and tasks observed through a developmental lens. Matrix Biol. 2004 Jan;22(7):521-38.
Wessells NK, Evans J. Ultrastructural researches of at an early stage morphogenesis and also cytodifferentiation in the embryonic mammalian pancreas. Dev Biol. 1968 Apr;17(4):413-46.
Wolff MS, Mirels L, Lagner J, Hand AR. Development of the rat sublingual gland: a light and electron microscope immunocytochemical study. Anat Rec. 2002 jan 01;266(1):30-42.
Thomas WW, Douglas JE, Rassekh CH. Accuracy the Ultrasonography and Computed Tomography in the testimonial of patient Undergoing Sialendoscopy because that Sialolithiasis. Otolaryngol Head Neck Surg. 2017 May;156(5):834-839.
Shea JA, Berlin JA, Escarce JJ, Clarke JR, Kinosian BP, Cabana MD, Tsai WW, Horangic N, Malet PF, Schwartz JS. Revised estimates of diagnostic check sensitivity and also specificity in suspected biliary street disease. Arch Intern Med. 1994 Nov 28;154(22):2573-81.
Denning CR, Huang NN, Cuasay LR, Shwachman H, Tocci P, Warwick WJ, Gibson LE. Cooperative study comparing three techniques of performing sweat tests to diagnose cystic fibrosis. Pediatrics. 1980 Nov;66(5):752-7.
Dutta SK, Bustin MP, Russell RM, Costa BS. Deficiency that fat-soluble vitamin in treated patients v pancreatic insufficiency. Ann Intern Med. 1982 Oct;97(4):549-52.
Domínguez-Muñoz JE, Hieronymus C, Sauerbruch T, Malfertheiner P. Fecal elastase test: evaluation of a new noninvasive pancreatic function test. Am J Gastroenterol. 1995 Oct;90(10):1834-7.
Heij HA, Obertop H, Schmitz PI, valve Blankenstein M, Westbroek DL. Evaluation of the secretin-cholecystokinin test for chronic pancreatitis through discriminant analysis. Scand J Gastroenterol. 1986 Jan;21(1):35-40.
Wu AJ. The oral component of Sjögren"s syndrome: pass the scalpel and also check the water. Curr Rheumatol Rep. 2003 Aug;5(4):304-10.
Asmussen K, Andersen V, Bendixen G, Schiødt M, Oxholm P. A new model for classification of condition manifestations in main Sjögren"s syndrome: testimonial in a retrospective long-term study. J Intern Med. 1996 Jun;239(6):475-82.
Soto-Rojas AE, Villa AR, Sifuentes-Osornio J, Alarcón-Segovia D, Kraus A. Dental candidiasis and Sjögren"s syndrome. J Rheumatol. 1998 May;25(5):911-5.
Bronstein MN, Sokol RJ, Abman SH, Chatfield BA, Hammond KB, Hambidge KM, Stall CD, Accurso FJ. Pancreatic insufficiency, growth, and nutrition in infants identified by child screening as having actually cystic fibrosis. J Pediatr. 1992 Apr;120(4 Pt 1):533-40.
Stathakis V, Kilkenny M, marks R. Descriptive public health of acne vulgaris in the community. Australas J Dermatol. 1997 Aug;38(3):115-23.
Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, Bowe WP, Graber EM, Harper JC, Kang S, Keri JE, Leyden JJ, Reynolds RV, Silverberg NB, Stein yellow LF, Tollefson MM, Weiss JS, Dolan NC, Sagan AA, Stern M, Boyer KM, Bhushan R. Indict of treatment for the administration of acne vulgaris. J to be Acad Dermatol. 2016 May;74(5):945-73.e33.
Liu A, Yang DJ, Gerhardstein PC, Hsu S. Relapse the acne complying with isotretinoin treatment: a retrospective examine of 405 patients. J drugs Dermatol. 2008 Oct;7(10):963-6.